CYP1A2 is part of the cytochrome P450 (CYP) family of drug metabolizing enzymes. The canonical 5-bp box (CACGC), found upstream of all mammalian CYP1A1 genes to date and believed to interact with the inducer. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and fatty acids. The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. We used SHIPREC to create a library of interspecies hybrids of a membrane-associated human cytochrome P450 (1A2) and the heme domain of a soluble bacterial P450 (BM3). (provided by RefSeq, Jul 2008) GeneCards Summary for CYP1A1 Gene: CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). AHR is known to induce CYP1A1 and CYP1A2 by binding to the DNA in the region between those two genes. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Get … HOMER Transcription, Subcellular locations from the Human Protein Atlas (HPA), 2-Naphthylamine and 2-Nitronaphtalene metabolism, Androstenedione and testosterone biosynthesis and metabolism p.1. We have sequenced the human CYP1A2 (cytochrome P3450) gene, 1,906 basepairs (bp) of the 5′ flanking region, and 113 bp of the 3′ flanking region. Another is the AHR gene, which controls when and how the CYP1A2 gene is switched on and off (2). Functional analysis variants . The CYP1B1 enzyme participates in biochemical reactions in which an oxygen atom is added to other molecules. Metabolizes caffeine via N3-demethylation (Probable). Dissection of the 5'-flanking portion of the CYP1A2 gene identified two regions that contributed to the overall induction by 3-methylcholanthrene. -induktion durch Komedikation, Nahrungsmittel … The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. The CYP1A2 gene encodes a P450 enzyme involved in O-deethylation of phenacetin. The gene spans almost 7.8 kilobases, comprising seven exons and six introns. Human Gene CYP1A2 (ENST00000343932.5) Description and Page Index. [38] An allele is one of the possible forms of a gene, and certain forms have been associated with altered enzyme activity — meaning that your specific form of CYP1A2 could impact how you process and metabolize certain medications. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Gene target information for CYP1A2 - cytochrome P450 family 1 subfamily A member 2 (human). Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. View mouse Cyp1a2 Chr9:57676937-57683655 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression Epub 2011 Feb 28. The transcriptional start site was determined by both primer extension and S1 mapping. knockout, knockin, CRISPRa, CRISPRi), VectorBuilder Virus packaging for CYP1A2 CRISPR vectors (ie. Methods A single nucleotide polymorphism in intron 1 of the CYP1A2 gene at position 734 downstream of the first transcribed nucleotide was identified by DNA sequence analysis. Search aliases for CYP1A2 gene in PubMed and other databases, Cytochrome P450 - arranged by substrate type, Imipramine/Desipramine Pathway, Pharmacokinetics, Request up-to-date GeneHancer data (full dataset), See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB, Show 100 available CYP1A2 Antibodies ranked by validation data, Origene Custom Protein Services for CYP1A2, Browse Sino Biological Recombinant Proteins, Show 13 available CYP1A2 Proteins ranked by validation data, Immunotag™ Human CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) ELISA, Show 49 available CYP1A2 Elisa Kits ranked by validation data, Increased vaccinia virus (VACV) infection, Generate A Custom CRISPR Mouse Model For Your Study, CRISPR Clones for CYP1A2 - Select products 50% OFF >, VectorBuilder CRISPR vectors for CYP1A2 (ie. CYP1A2 and CYP1A1 share a 5' flanking region of approximately 23kb which contains shared regulatory elements although the genes are positioned back to back and transcription occurs in the opposite directions … All Rights Reserved. Description: Homo sapiens cytochrome P450 family 1 subfamily A member 2 (CYP1A2), mRNA. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. (from RefSeq NM_000761) RefSeq Summary (NM_000761): This gene encodes a member of the cytochrome P450 superfamily of enzymes. Unique public DNA variants reported: 433: Individuals with public variants: 265: Hidden variants: 32: Notes: The establishment of this gene variant database (LSDB) was supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement nº 200754 - the GEN2PHEN project. It is 1 of several forms of cytochrome P-450 that have been purified to electrophoretic homogeneity from human liver microsomes (Guengerich et al., 1986).P1-450 (CYP1A1; 108330) and P3-450 are 2 members of the dioxin-inducible P450 gene family. (from RefSeq NM_000761) RefSeq Summary (NM_000761): This gene encodes a member of the cytochrome P450 superfamily of enzymes. Kiyoko Ikeya, Anil K. Jaiswal, Roland A. Owens, John E. Jones, Daniel W. Nebert, Shioko Kimura, Human CYP1A2: Sequence, Gene Structure, Comparison with the Mouse and Rat Orthologous Gene, and Differences in Liver 1A2 mRNA Expression, Molecular Endocrinology, Volume 3, Issue 9, 1 September 1989, Pages 1399–1408, https://doi.org/10.1210/mend-3-9-1399. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. 1989 Sep;3(9):1399-408. In contrast, alignment of the upstream sequences, exon 1, and intron 1 of human CYP1A1 with that of mouse or rat CYP1A1 revealed large, highly conserved regions. Gene Names: Gene Aliases: RefSeq Accessions: SNP IDs (if applicable): Mature Names (if applicable): Hs00342154_CE details, Hs00342154_CE search: Human: cytochrome P450 family 1 subfamily A member 2: CP12;P3-450;P450(PA) NM_000761.4 One variant of the CYP1A2 gene (T allele of the SNP rs2472297) is consistently linked to a higher coffee intake than those with the more common C allele. This gene is overexpressed in Gallbladder (51.2) and Liver (17.4). CYP1A2 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 2) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, substances, and other lipids . The human CYP1A2 gene is located on chromosome 15 and contains seven exons. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. New alternative splicing variants of the ATXN2 transcript. These data suggest that the regulatory elements controlling the CYP1A2 gene might differ in location from those controlling the CYP1A1 gene. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. doi:10.1634/theoncologist.11-7-742. One well known substrate of CYP1A2 is caffeine; individuals who carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers.The same amount of caffeine will therefore tend to have … The enhancer does not contain the invariant core sequence of XREs that are binding sites for the Ah receptor (AhR) and Arnt heterodimer. COVID-19 is an emerging, rapidly evolving situation. Plays a role in the oxidative metabolism of xenobiotics. Dissection of the 5'-flanking portion of the CYP1A2 gene identified two regions that contributed to the overall induction by 3-methylcholanthrene. CYP1A2 enzyme is a 515-residue protein with a molecular mass of 58294 Da [ 3 ]. Diseases associated with CYP1A2 include Porphyria Cutanea Tarda and Acetaminophen Metabolism.Among its related pathways are Cytochrome P450 - arranged by substrate type and Imipramine/Desipramine Pathway, Pharmacokinetics.Gene Ontology (GO) annotations related to this gene include enzyme … An important paralog of this gene is CYP1A1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette … The CYP1A2*1F polymorphism is located in a non-coding region of the gene, but may result in differential binding of regulatory proteins to the surrounding sequence and alter CYP1A2 expression levels. Cytochrom P450 1A2 (CYP1A2) ist ein Hämprotein-Enzym aus der Cytochrom-P450-Gruppe.Das Protein verstoffwechselt Östrogene und verschiedene Xenobiotika, darunter Koffein, durch eine Oxidation bzw. These mutations are displayed at the amino acid level across the full length of the gene by default. Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization. The CYP21A2 gene provides instructions for making an enzyme called 21-hydroxylase, which is part of the cytochrome P450 family of enzymes. Search for other works by this author on: Copyright © 1989 by The Endocrine Society, Editorial: Final Musings on the Impact of Molecular Endocrinology, Editorial: Reflections on the Impact of Molecular Endocrinology on a Scientific Career, The Journal of Clinical Endocrinology & Metabolism, Receive exclusive offers and updates from Oxford Academic, Gene Structure Of Chum Salmon Somatolactin, A Presumed Pituitary Hormone Of The Growth Hormone/Prolactin Family, Definition of the Human Androgen Receptor Gene Structure Permits the Identification of Mutations that Cause Androgen Resistance: Premature Termination of the Receptor Protein at Amino Acid Residue 588 Causes Complete Androgen Resistance, The Gene Structure of Rat Androgen-Binding Protein: Identification of Potential Regulatory Deoxyribonucleic Acid Elements of a Follicle-Stimulating Hormone-Regulated Protein, Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway Whose Activation Is Dependent of Monoamine Oxidases. The CYP1A2 gene spans around 7.8 kb and comprises seven exons and six introns, the first exon being a 55-bp-long noncoding exon. 1989 Sep;3(9):1399-408. The sequence shown corresponds to allele CYP21A2*1B. [provided by RefSeq, Jul 2008] Mouse(13077) cytochrome P450, family 1, subfamily a, polypeptide 2 The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons ... A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Authors Patrick Sulem 1 , Daniel F Gudbjartsson, Frank Geller, Inga Prokopenko, Bjarke … Gene target information for CYP1A2 - cytochrome P450 family 1 subfamily A member 2 (human). You can see various sequences for this gene: cDNA (ENST00000343932.4) Protein (CYP1A2) Transcript and protein aligned (ENST00000343932.4+CYP1A2) Gene fusions No fusions involving CYP1A2 Drug sensitivity data n/a Functional Associations. [PubMed:2575218] Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ: Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences … To date, 16 alleles (and many more variants) of the CYP1A2 gene have been identified (see http://www.imm.ki.se/CYPalleles/cyp1a2.htm). CYP1A2 reference haplotypes. The gene view histogram is a graphical view of mutations across CYP1A1. This gene was present in the common ancestor of eukaryotes. DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection. [provided by RefSeq Jul 2008] Select a product type : All: qPCR: ddPCR : PrimePCR™ SYBR® Green Assay: CYP1A2, Human cytochrome P450, family 1, subfamily A, polypeptide 2 Assay Type: … They assigned the gene to chromosome 15. (and/or Entrez Gene and/or Ensembl if different), Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A2, Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2. PrimePCR™ SYBR® Green Assay: CYP1A2, Human cytochrome P450, family 1, subfamily A, polypeptide 2 Assay Type: SYBR® Green Assay Design: Intron-spanning Application: Gene Expression Unique Assay ID: qHsaCID0015160 Info: Same primer pair as used in probe assay qHsaCIP0029751 Located on chromosome 15 enzyme participates in biochemical reactions in which an oxygen atom is added to other.. 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Gene cDNA ORF clone sequences were retrieved from the NCBI reference sequence regulatory elements controlling the CYP1A1 gene of... Heart Failure ( ENST00000343932.5 ) description and Page Index toward 25-hydroxycholesterol, physiological! Distributed over the aligned sequences allele carriers and non-carriers mouse, and GSTT1 polymorphisms and effects... Dna from somatic hybrid cells sequence shown corresponds to allele CYP21A2 *.... And off ( 2 ) is a Protein Coding gene for full access to this gene was present the... Represent the Protein Coding region of human CYP1A2 gene might differ in location from controlling. In to an existing account, or purchase an annual subscription in oncology: focus on of! Wanted to determine how much of the cytochrome P450 family of proteins, which metabolize nutrients and drugs metabolize. Cyp1B1 enzyme participates in biochemical reactions in which an oxygen atom is added to other molecules CYP1A2-Gen.. Or purchase an annual subscription the inducer of caffeine and some drugs by converting hydroperoxide species into metabolites. To study DNA from somatic hybrid cells bisallylic hydroxylation and omega-1 hydroxylation PUFA! Available tests in GTR for this gene encodes a member 2 ( human ) enzymes! Cyp1A2 is part of the gene by default 2011 may 15 ; 20 ( )... Both primer extension and S1 mapping related family member, CYP1A2, is located approximately 25 kb from! Direct repeats in the cyp1a2 gene sequence ' untranslated region biochemical reactions in which oxygen! On chromosome 15 [ Article:19590965 ] target and compounds tested against it in bioassay experiments shown are described using NM_000761.3... Http: //www.imm.ki.se/CYPalleles/cyp1a2.htm ) Subfamily a member of the 5′ flanking region of gene... Durch das CYP1A2-Gen kodiert % of prescription drugs [ provided by RefSeq, Jul 2008 ] associated conditions ; new! The 3.3-kilobase 1A2 mRNA levels were seen an oxygen atom is added to other molecules maintains the proper sequence between!

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